KMID : 0387720070180010066
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Korean Journal of Blood Transfusion 2007 Volume.18 No. 1 p.66 ~ p.69
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A Case of ABO Discrepancy due to Anti-IH
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Lee Yang-Soon
Lee Sang-Guk Kim Sin-Young Baek Eun-Jung Kim Hyun-Ok
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Abstract
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The patient was a 70-year-old woman with hypertension and end stage renal disease, and she presented with left wrist pain due to falling a day before admission. On admission, laboratory testing revealed a hemoglobin level of 6.7 g/dL, and a physician ordered 2 units of packed RBCs. She had never received a RBC transfusion in the past. The ABO grouping showed a discrepancy between the cell type AB and serum type O, and the irregular antibody screening was negative. Crossmatchings with group AB and group O RBCs were incompatible. Anti-I, which is a cold antibody, was inferred because the degree of agglutination was decreased after warming. However, crossmatching with group O RBCs, which are the universal donor blood, was positive and the anti-IH was considered to be the specificity of the irregular antibody. The patient¡¯s serum did not react with group O cord (i) blood cells and anti-I was then considered. The genotype of this patient was AB, and it was inferred that the ABO discrepancy was due to anti-IH.
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KEYWORD
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ABO discrepancy, Anti-IH, Universal donor blood
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